All of these use the CP210xManufacturing.DLL to communicate with the device. The version of this .DLL must be compatible with the version of the Virtual COM Port (VCP) drivers you are using. For example, the 4.x utilities won't work with the 5.x driver, or vice-versa. If you have recently upgraded to the newest version of the driver and are seeing a problem, download the latest version of the utilities to access the device.
The latest versions of these tools are available here.